Aim: To register Christian saints worshipped as the protectors from diseases and, basing upon the hagiographic data, to explain the origin of the protective qualities that have been attributed to the saints Methods: 1) elaboration of literature dealing with saints' hagiographies, sacral iconography and liturgy; 2) visiting churches, monasteries, and museums Results: The research of sacral literature and the works of art, performed during the last several years, has revealed more than 150 Christian saints protecting from about 50 diseases and symptoms, as well as ÒcoveringÓ the most important body parts and organs. The highest number of saints has been invoked against plague (23), 18 has been invoked against headache and fever, 13 against epilepsy, and 11 against sore. Individually, after universal helper Holly Virgin Mary, the most often invoked are Anthony of Padua, Francis of Assisi, and Egidius (each being ÒresponsibleÓ for 6 diseases), as well as Bartholomew the Apostle, John the Baptist, Catherine of Alexandria, and Christopher (5 diseases each). Other, less invoked saints are mostly ÒspecializedÓ for one or two diseases or organs. Conclusion: The examples presented in this work demonstrate that, by using interdisciplinary approach to sacral art and tradition, one can arrive to numerous valuable data surpassing a mere religious message. These data present significant contributions to the history of medicine in its broadest sense.