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Scientific paper - Original scientific paper
Treatment With Medicinal Mushroom Extract Mixture Inhibits Translation and Reprograms Metabolism in Advanced Colorectal Cancer Animal Model as Evidenced by Tandem Mass Tags Proteomics Analysis
Frontiers in Pharmacology, 11 (2020); 1-18. https://doi.org/10.3389/fphar.2020.01202
Jakopović, Boris; Horvatić, Anita; Klobučar, Marko; Gelemanović, Andrea; Grbčić, Petra; Oršolić, Nada; Jakopovich, Ivan; Kraljević Pavelić, Sandra

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Jakopović, B., Horvatić, A., Klobučar, M., Gelemanović, A., Grbčić, P., Oršolić, N. ... Kraljević Pavelić, S. (2020). Treatment With Medicinal Mushroom Extract Mixture Inhibits Translation and Reprograms Metabolism in Advanced Colorectal Cancer Animal Model as Evidenced by Tandem Mass Tags Proteomics Analysis. Frontiers in Pharmacology, 11., 1-18. doi: 10.3389/fphar.2020.01202

Jakopović, Boris, et al. "Treatment With Medicinal Mushroom Extract Mixture Inhibits Translation and Reprograms Metabolism in Advanced Colorectal Cancer Animal Model as Evidenced by Tandem Mass Tags Proteomics Analysis." Frontiers in Pharmacology, vol. 11, 2020, pp. 1-18. https://doi.org/10.3389/fphar.2020.01202

Jakopović, Boris, Anita Horvatić, Marko Klobučar, Andrea Gelemanović, Petra Grbčić, Nada Oršolić, Ivan Jakopovich and Sandra Kraljević Pavelić. "Treatment With Medicinal Mushroom Extract Mixture Inhibits Translation and Reprograms Metabolism in Advanced Colorectal Cancer Animal Model as Evidenced by Tandem Mass Tags Proteomics Analysis." Frontiers in Pharmacology 11 (2020): 1-18. https://doi.org/10.3389/fphar.2020.01202

Jakopović, B., et al. (2020) 'Treatment With Medicinal Mushroom Extract Mixture Inhibits Translation and Reprograms Metabolism in Advanced Colorectal Cancer Animal Model as Evidenced by Tandem Mass Tags Proteomics Analysis', Frontiers in Pharmacology, 11, pp. 1-18. doi: 10.3389/fphar.2020.01202

Jakopović B, Horvatić A, Klobučar M, Gelemanović A, Grbčić P, Oršolić N, and sur.. Treatment With Medicinal Mushroom Extract Mixture Inhibits Translation and Reprograms Metabolism in Advanced Colorectal Cancer Animal Model as Evidenced by Tandem Mass Tags Proteomics Analysis. Frontiers in Pharmacology [Internet]. 2020 [cited 2025 February 15];11:1-18. doi: 10.3389/fphar.2020.01202

B. Jakopović, et al., "Treatment With Medicinal Mushroom Extract Mixture Inhibits Translation and Reprograms Metabolism in Advanced Colorectal Cancer Animal Model as Evidenced by Tandem Mass Tags Proteomics Analysis", Frontiers in Pharmacology, vol. 11, pp. 1-18, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:412548. [Accessed: 15 February 2025]

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Title (english)Treatment With Medicinal Mushroom Extract Mixture Inhibits Translation and Reprograms Metabolism in Advanced Colorectal Cancer Animal Model as Evidenced by Tandem Mass Tags Proteomics Analysis
AuthorBoris Jakopović
AuthorAnita Horvatić
AuthorMarko Klobučar
AuthorAndrea Gelemanović
AuthorPetra Grbčić
AuthorNada Oršolić
AuthorIvan Jakopovich
AuthorSandra Kraljević Pavelić
Author's institutionUniversity of Rijeka
Faculty of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Colorectal cancer (CRC) is the third most frequent cancer type in both males and females, with about 35% of patients being diagnosed in stage IV metastatic disease. Despite advancements in treatment, life expectancy in patients with metastatic disease is still not satisfying. Due to frequent drug resistance during conventional and targeted cancer treatments, the development and testing of multi-target therapies is an important research field. Medicinal mushrooms specific isolated compounds as well as complex extract mixtures have been studied in depth, and many mushroom species have been proven to be non-toxic multi-target inhibitors of specific oncogenic pathways, as well as potent immunomodulators. In this study, we have performed a tandem mass tags qualitative and quantitative proteomic analyses of CT26.WT colon cancer tumor tissues from Balb/c mice treated with the studied medicinal mushroom extract mixture, with or without 5-fluorouracil. Besides significantly improved survival, obtained results reveal that Agarikon.1 alone, and in combination with 5-fluorouracil exert their anticancer effects by affecting several fundamental processes important in CRC progression. Bioinformatic analysis of up- and downregulated proteins revealed that ribosomal biogenesis and translation is downregulated in treatment groups, while the unfolded protein response (UPR), lipid metabolism and tricarboxylic acid cycle (TCA) are upregulated. Moreover, we found that many known clinical biomarkers and protein clusters important in CRC progression and prognosis are affected, which are a good basis for an expanded translational study of the herein presented treatment.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleFrontiers in Pharmacology
Numberingvol. 11, pp. 1-18
p-ISSN1663-9812
DOIhttps://doi.org/10.3389/fphar.2020.01202
URN:NBNurn:nbn:hr:184:412548
Publication2020
Document URLhttp://bib.irb.hr/1078886
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-03-14 11:14:39