Due to its achievements and continuous work in the four decades of its existence, Medicina, professional and scientific journal of the Croatian Medical Association, Rijeka Branch, has proved to be one of the basic interconnections of Rijeka medicine, from the times when its highest achievements began to be reached until these anniversary days. It was founded with unique scientific efforts and the enthusiasm of a number of top class medical experts, who, in the beginning of the second half of the last century, realised important programmes in the field of clinical medicine, of public health care and in establishing highest institutions of medical education. Medicina is a journal of general medicine, but it has always endeavoured to follow the latest topics and achievements of medical specialities and specifics in the function of the medical profession and science of this region. Owing to their effort, it has become part of medical professionals and medical institutions themselves, assuming recognisable features representing this medical environment. This is a short review and recollection of the times when Medicina, this exemplary medical journal that fills us with pride, was founded and first published, together with its prominent achievements